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Increased risk of cancer in the descendants of syrian hamsters exposed prenatally to diethylnitrosamine (DEN)
Author(s) -
Mohr U.,
Emura M.,
Kamino K.,
Steinmann J.,
Kohler M.,
Morawietz G.,
Dasenbrock C.,
Tomatis L.
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910630116
Subject(s) - cancer , medicine , syrian hamsters , carcinogen , nitrosamine , physiology , endocrinology , cancer research , biology , hamster , genetics
Transmission of site‐specific tumorigenicity (papillomas in larynx and trachea) of diethylnitrosamine (DEN) to the 2 subsequent generations (F 1 and F 2 ) was studied using an out‐bred strain (Han:AURA) of pregnant Syrian golden hamsters (P generation), which were treated i.p. with 10 mg/kg b.w. of DEN on day 12, 13 or 14 of gestation. Laryngotracheal papillomas were induced by DEN in the P and F 1 generations only, while these tumours did not occur in the F 2 generation. Spontaneously occurring tumours, including uterine adenocarcinomas, lymphomas, and laryngotracheal neuro‐endocrine cell tumours, were observed at higher incidences among the F 2 animals derived from the P generation hamsters treated with DEN only on day 13 or 14 of gestation. In the same animals, the ratio of malignant to benign tumours was considerably higher than in controls. In addition, the F 2 hamsters derived from the DEN‐treated P generation showed more frequent multiple organ involvement in tumorigenesis than the F 2 controls. Several uncommon malignant tumours were detected in the F 2 offspring, possibly the result of damage caused to germ cells by the prenatal exposure of F 1 Syrian hamsters to DEN.