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Second primary cancers in patients with carcinoma in situ of the uterine cervix. The norwegian experience 1970–1992
Author(s) -
Bjørge Tone,
Hennig Elin M.,
Skare Gry B.,
Søreide Odd,
Thoresen Steinar Ø.
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910620108
Subject(s) - medicine , carcinoma in situ , cervix , cancer , cancer registry , carcinoma , population , corpus uteri , gynecology , lung cancer , relative risk , incidence (geometry) , risk factor , vaginal cancer , cervical cancer , confidence interval , oncology , physics , environmental health , optics
Multiple primary cancers in the same individual occur rarely. Consequently, a large number of cancer patients have to be followed for long periods to obtain adequate information about their risk of subsequent tumour development. Studies of multiple malignancies are of interest, since they may provide information on common or opposite risk factors. In the present study, the risk of second primary cancers following carcinoma in situ of the uterine cervix diagnosed in Norway in the period 1970–1992 was examined and quantified. Altogether, 37,001 patients with carcinoma m situ were followed from the date of diagnosis until 31 December 1992. The follow‐up period was divided into 5‐year intervals. The results were expressed as standardized incidence ratios (SIR = O/E), and their 95% confidence intervals were given. A total of 1,037 second primary cancers in 989 individuals were identified. There was no overall excess of second primary cancers. However, there were differences depending on the site: cancers of the oesophagus, nose, nasal cavities, trachea, bronchus, lung, vulva, vagina, bladder and other urinary organs, and other skin cancers, excluding basal‐cell carcinoma, occurred more frequently. A lower risk than expected was noted for cancer of the cervix uteri and cancer of the corpus uteri. There was a rising trend with time in the observed/expected ratio for cancer of urinary organs. In the group of patients evaluated, the likelihood of subsequent tumour development was no greater than in the general female population. Nevertheless, cancer sites of higher and of lower risk than expected were identified among the carcinoma‐ In situ patients. © 1995 Wiley‐Liss Inc.