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Human papillomavirus and cervical intraepithelial neoplasia grade II‐III: A population‐based case‐control study
Author(s) -
Olsen Anne O.,
Gjøen Kirsti,
Sauer Torill,
Ørstavik Ivar,
Næss Oddvar,
Kierulf Knut,
Sponland Geir,
Magnus Per
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910610306
Subject(s) - odds ratio , cervical intraepithelial neoplasia , cervix , medicine , confidence interval , case control study , cervical cancer , confounding , gynecology , logistic regression , human papillomavirus , population , hpv infection , papillomaviridae , gastroenterology , cancer , environmental health
The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co‐factors is unclear. This population‐based case‐control study in Norwegian women 20–44 years of age included 103 cases with histologically confirmed CIN II–III and 234 age‐matched and randomly selected controls. Cytological specimens from the cervix were analyzed using the polymerase chain reaction (PCR). In all, 91% of the cases and 15% of the controls were HPV DNA positive, giving a crude odds ratio (OR) of 67.2 (95% confidence interval: 28.6–157.5). The association between HPV 16 and CIN II–III was even stronger (crude OR = 123.9; 46.7 ‐ 328.5). In logistic regression analysis, additional to HPV, only a high number of sexual partners and a low educational level contributed independently to the risk. The adjusted OR for the association between HPV and CIN II–III was 72.8 (95% Cl: 27.6–191.9). The association between HPV and CIN remains very strong even after adjustment for proposed confounding factors. The results therefore support the role of HPV as a causative agent in the development of CIN. © 1995 Wiley‐Liss, Inc .