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Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP‐470, and mitomycin c on the growth and liver metastasis of human colon cancer
Author(s) -
Konno Hiroyuki,
Tanaka Tatsuo,
Matsuda Iwao,
Kanai Toshikazu,
Maruo Yuji,
Nishino Nobuhiko,
Nakamura Satoshi,
Baba Shozo
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910610221
Subject(s) - metastasis , angiogenesis , angiogenesis inhibitor , mitomycin c , medicine , transplantation , colorectal cancer , cancer , saline , neovascularization , liver cancer , cancer research , pathology , oncology , surgery
Angiogenesis inhibitors have attracted considerable interest. The anti‐tumor and anti‐metastatic effects of TNP‐470, an angiogenesis inhibitor, and mitomycin C (MMC), a representative anti‐neoplastic agent, were investigated using a xenotrans‐planted human colon cancer, TK‐4. Suturing of small pieces of TK‐4 tumors to the cecal wall in nude mice (orthotopic transplantation) induced liver metastasis. Mice were randomly divided into 3 groups; a control group given saline solution, a group receiving TNP‐470 and a group receiving MMC. TNP‐470 was given s.c. on alternate days for 5 weeks from day 10 after cecal transplantation and MMC was administered intraperitoneally (i.p.) once a week from day 10 after cecal transplantation. MMC significantly inhibited cecal tumor growth. In the control group, liver metastases developed in 9 out of 10 mice, including 3 with more than 20 metastatic foci. Liver metastasis also developed in 8 out of 10 mice receiving MMC, 2 of which had many metastases. In contrast, liver metastasis developed in only 2 out of 8 mice in the TNP‐470 group and neither of these animals had numerous metastases. © 1995 Wiley‐Liss, Inc .