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Nucleotide sequence analysis of a full‐length human T‐cell leukemia virus type I from adult T‐cell leukemia cells: A prematurely terminated PX open reading frame II
Author(s) -
S.Chou Kuan,
Okayama Akihiko,
Tachibaobuyoshi,
Lee TunHou,
Essex Max
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910600522
Subject(s) - provirus , open reading frame , leukemia , virology , biology , nucleic acid sequence , frameshift mutation , virus , t cell leukemia , microbiology and biotechnology , genetics , peptide sequence , gene , genome , mutation
Human T‐cell leukemia virus type 1 (HTLV‐I) is etiologically associated with adult T‐cell leukemia/lymphoma (ATL). The prototypic HTLV‐I, ATK, is the only full‐length provirus cloned from uncultured leukemic cells and completely sequenced prior to this study. We have determined the complete nucleotide sequence of another full‐length HTLV‐I provirus cloned directly from leukemic cells. A premature termination codon was found in the second open reading frame (orf II) of the pX region. Our finding indicates that open reading frame II of the HTLV‐I pX region is not required for outgrowth of ATL leukemic clones in vivo .