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Karyotypic features of malignant tumors of the nasal cavity and paranasal sinuses
Author(s) -
Jin Yucsheng,
Mertens Fredrik,
Arheden Kristina,
Mandahl Nils,
Wennerberg Johan,
Dictor Michael,
Heim Sverre,
Mitelman Felix
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910600512
Subject(s) - esthesioneuroblastoma , paranasal sinuses , karyotype , pathology , nasal cavity , biology , cytogenetics , chromosome , anatomy , medicine , genetics , gene
Cytogenetic analysis of short‐term cultures from 6 tumors of the nasal cavity and paranasal sinuses—one esthesioneuroblas‐toma, 2 adenocarcinomas and 3 squamous‐cell carcinomas (SCC)—revealed clonal chromosome aberrations in all cases. The esthesioneuroblastoma had a complex hyperdiploid karyotype. None of the aberrations was similar to those previously described in short‐term cultures or established cell lines from esthesioneuroblastomas. The 2 adenocarcinomas had complex karyotypic changes, which in both cases included rearrangements of bands 9p22 and 14q11. One SCC had 5 unrelated pseudodiploid clones, I displayed a highly complex karyotype, including rearrangement of band 11 q 13, and I had simple karyotypic changes with loss of 6q material and gain of 3q. These findings are similar to those described in head‐and‐neck SCC at other sites.