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Cervical cancer and herpes simplex virus type 2: Case‐control studies in Spain and Colombia, with special reference to immunoglobulin‐G sub‐classes
Author(s) -
Muñoz Nubia,
Kato Ikuko,
Bosch F. Xavier,
De Sanjosé Silvia,
Sundquist ViviAnne,
Izarzugaza Isabel,
Gonzalez Luis Carlos,
Tafur Luis,
Gili Miguel,
Viladiu Pablo,
Navarro Carmen,
Moreo Pilar,
Guerrero Eloisa,
Shah Keerti V.,
Wahren Britta
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910600403
Subject(s) - herpes simplex virus , serology , antibody , cervical cancer , medicine , population , immunoglobulin g , immunology , cancer , virus , virology , environmental health
Two casecontrol studies, including 449 histologically confirmed cases of cervical intraepithelial neoplasia (CIN) III and 425 controls, and 2 studies on invasive cervical cancer, involving 316 histologically confirmed cases and 330 population controls, were conducted in Colombia and Spain to assess the role of herpes simplex virus type 2 (HSV‐2) in cervical neoplasia. Antibodies to this virus were also measured in the sera of 931 husbands of cases and controls. A serological assay using typespecific antigens, glycoprotein C for type I (gC‐1) and glycoprotein G for type 2 (gG‐2) was employed. Immunoglobulin‐G (IgG) subclasses, IgG 1 and lgG3 r were measured in women positive for HSV‐2 antibodies. No increase in risk of CIN III or invasive cancer was found in women whose sera or whose husbands' sera were positive to HSV‐2. However, compared with women negative to HSV‐2, the risk of CIN III progressively increased with increasing levels of IgG 1 . The trend was statistically significant in Colombia. There was also a statistically significant increasing trend in risk of invasive cancer with levels of IgG 1 in Spain. The levels of lgG 3 and its ratio to lgG 1 , which may indicate recurrent infections, were not associated with the risk of either type of cancer. When the association with lgG 1 was analyzed by human papillomavirus (HPV) DNA status, as determined by polymerase chain reaction, the trend was clearer in women whose HPV status was not determined or in those with negative HPV DNA. These results suggest that the role of HSV‐2 is merely marginal and do not support the hypothesis that recurrent HSV‐2 infections are of importance for cervical neoplasia.