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Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers
Author(s) -
Yana Ikuo,
Kurahashi Hiroki,
Nakamori Shoji,
Kameyama Masao,
Nakamura Tsutomu,
Takami Motohisa,
Mori Takesada,
Takai Shinichiro,
Nishisho Isamu
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910600207
Subject(s) - loss of heterozygosity , colorectal cancer , biology , carcinogenesis , locus (genetics) , deleted in colorectal cancer , tumor suppressor gene , cancer research , allele , tumor progression , metastasis , chromosome , gene , genetics , cancer
To date, several tumor‐suppressor genes responsible for the tumorigenesis of colorectal cancer have been identified. However, studies of loss of heterozygosity (LOH) have suggested several chromosomal regions which may contain additional tumor‐suppressor genes for colorectal cancer. To determine the extent and variation of allelic loss on 22q, on which LOH has been frequently observed, a total of 68 sporadic colorectal cancers was examined for LOH on the chromosome arm by means of 16 polymorphic DNA markers. LOH was observed in 28 tumors (41 %), of which 9 showed LOH at all informative loci. The remaining 19 tumors showed variable patterns of partial loss on 22q, delimiting the smallest region of overlap (SRO) between D22S90 and D22S94. Moreover, LOH within the SRO correlated with a progression in terms of Dukes' stages. These results suggest that an additional tumor‐suppressor gene for colorectal cancer may exist on 22q distally to the NF2 locus and that inactivation of the gene may possibly play a role in the progression or metastasis of colorectal cancers. © 1995 Wiley‐Liss, Inc.