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Oncogene amplifications in early‐stage human prostate carcinomas
Author(s) -
Latil Alain,
Baron JeanChristophe,
Cussenot Olivier,
Fournier Georges,
BocconGibod Laurent,
Le Duc Alain,
Lidereau Rosette
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910590510
Subject(s) - oncogene , carcinogenesis , gene duplication , southern blot , prostate , biology , cancer research , cancer , gene , stage (stratigraphy) , prostate cancer , pathology , microbiology and biotechnology , medicine , genetics , cell cycle , paleontology
Oncogene amplifications are frequently found in solid tumours and are often associated with more aggressively growing forms of human cancer. The proto‐oncogenes c‐ myc , c‐ erb B2/ neu and the IIq13 band are the most frequently amplified regions in adenocarcinomas of various origins. The present study was undertaken to define whether c‐ myc , int 2/FGF3 (11q13 region) and c‐ erb B2/ neu genes are involved in prostate tumorigenesis. Tumours and peripheral lymphocyte DNA from 21 localized early‐stage prostatic carcinomas were analysed by Southern‐blot electrophoresis for amplification of the c‐ myc and c‐ erb B2/ neu genes and the 11q13 region (int2/FGF3). We detected no amplification of these 3 oncogenes in our panel.