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Repair of cisplatin‐DNA adducts by protein extracts from human ovarian carcinoma
Author(s) -
Jones Sandra L.,
Hickson Ian D.,
Harris Adrian L.,
Harnett Paul R.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910590317
Subject(s) - ovarian carcinoma , cisplatin , dna , cancer research , dna repair , carcinoma , medicine , oncology , ovarian cancer , biology , chemotherapy , genetics , cancer
Human ovarian carcinoma exhibits a spectrum of responses to treatment with cisplatin, ranging from marked sensitivity to relative resistance. Variations in the efficiency with which cells repair cisplatin‐DNA adducts may in part determine cisplatin sensitivity. We have investigated the use of a novel cell‐free assay of nucleotide excision repair of platinated DNA to assess the DNA repair capacity of direct biopsies of untreated human ovarian carcinoma. In this pilot study, ovarian carcinoma extracts performed in vitro excision repair of platinated DNA. Moreover, tumors from different individuals varied as much as I O‐fold in their repair capacity in this assay. © 1994 Wiley‐Liss, Inc.