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The human zinc‐finger protein‐7 gene is located 90 kb 3′ of MYC and is not expressed in Burkitt lymphoma cell lines
Author(s) -
Gallego Marta I.,
Lazo Pedro A.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910580618
Subject(s) - biology , gene , chromosomal translocation , lymphoma , zinc finger , cell culture , microbiology and biotechnology , gene expression , chromosome , phenotype , breakpoint , genetics , cancer research , transcription factor , immunology
The zinc‐finger gene‐7 (ZNFT) was located 90 kb 3′ of MYC on human chromosome 8 band q24 by pulsed‐field gel electropho‐resis (PFGE). This position lies between the MLV14 and BVRI loci, 2 variant translocation breakpoints in Burkrtt tymphomas. The structure of the ZNF7 gene was not altered by translocations in Burkitt‐lymphoma cell lines as shown by its germline‐restriction map configuration. The chromosomal region surrounding the ZNF7 gene was extensively methylated. The ZNF7 gene was not expressed in 19 BL cell lines. Expression was detected only in the BL41 and BL47 cell lines and in the SW756 cervical‐carcinoma cell line. The UNA in each was of a different size. We postulate that the lack of ZNF7 expression in Burkitt lymphomas might contribute to the tumor phenotype.