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Overexpression of the MET /HGF receptor in ovarian cancer
Author(s) -
Di Renzo M. Flavia,
Olivero Martina,
Katsaros Dionyssios,
Crepaldi Tiziana,
Gaglia Piero,
Zola Paolo,
Sismondi Piero,
Comoglio Paolo M.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910580507
Subject(s) - hepatocyte growth factor , biology , ovarian cancer , ovary , cancer research , oncogene , receptor , cancer , pathology , medicine , endocrinology , cell cycle , biochemistry , genetics
The MET oncogene encodes the receptor for Hepatocyte Growth Factor/Scatter Factor, a unique growth factor that induces not only proliferation of epithelial cells, but also cell motility and invasiveness. DNA level and expression of the Met/HGF receptor gene were examined with Southern‐ and Western‐blot analyses, respectively, in human ovary, benign ovarian tumors and epithelial ovarian carcinomas. The Met/HGF receptor was detectable in the surface epithelium of normal ovary. The level of expression was unchanged in benign ovarian tumors of various origins. Fourteen out of 67 malignant carcinomas (20%) showed a 3‐to 10‐fold increase in expression. In 5 additional cases the Met/HGF protein was overexpressed over 50‐fold. This represents a total of 28% of cases. Overexpression was not associated with MET gene amplification. Overexpressing tumors belonged to different histotypic variants, but showed a well‐differentiated phenotype. Clinically, overexpression was associated with disease at any pathologic stage, but was significantly correlated with premenopausal status of patients. These data suggest that expression of the Met/HGF receptor may add a selective growth advantage to a narrow subset of differentiated ovarian cancers in premenopausal patients.