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DNA ploidy in primary fallopian‐tube carcinoma using image cytometry
Author(s) -
Rosen Alexander C.,
Graf Anton H.,
Klein Matthias,
Lahousen Michael,
Vavra Norbert,
Reiner Angelika,
Hacker Gerhard W.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910580309
Subject(s) - grading (engineering) , pathology , ploidy , cytometry , aneuploidy , biology , carcinoma , fallopian tube , dna , flow cytometry , medicine , microbiology and biotechnology , anatomy , chromosome , genetics , gene , ecology
Determination of DNA ploidy in 61 samples of primary Fallopian‐tube carcinoma (FTC) by use of image cytometry is presented. Of these samples, 48 showed an aneuploid DNA content. Patients with euploid DNA content showed a median survival time of 33.8 months compared to 24.5 months for aneuploid cases. A high incidence of aneuploid tumors was consistently observed among all FIGO stages and in all groups of histologic grading. However, no correlation between ploidy and FIGO stage or histologic garding could be demonstrated. This observation could be regarded as a marker for the high aggressiveness of FTC which has been repeatedly described in the past.