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A novel strategy of C‐ myc oncogene in NK activity regulation not related to the W6/32 MHC class‐I epitope
Author(s) -
La Cava Antonio,
Carbone Ennio,
Moscarella Anna,
Barcová Mária,
Salzano Salvatore,
Zappacosta Serafino,
Fontana Silvia
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910580120
Subject(s) - epitope , transfection , biology , mhc class i , effector , major histocompatibility complex , gene , lysis , cell culture , microbiology and biotechnology , gene expression , genetics , antigen
The C‐ myc gene encodes a nuclear protein whose precise function is still not folly understood. Introduction of a c‐ myc gene into a number of cell lines leads to an increase in their susceptibility to NK‐cell lysis. It was reported earlier that c‐ myc can induce a decrease in the membrane expression of the MHC class‐1 molecules and this may be one of the factors that render target cells relatively more susceptible to NK lysis. In this contribution, we show, in a human LCL line transfected with a constitutively active c‐ myc gene, an increased sensitivity to NK lysis, which correlates with an augmented effector‐target binding ability of c‐ myc ‐transfected LCLs and with a high 1CAM‐1 expression rather than with down‐regulation of MHC class‐l W6/32 epitope expression. © 1994 Wiley‐Liss, Inc.