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Increased production of immune activation marker neopterin by colony‐stimulating factors in gynecological cancer patients
Author(s) -
Marth Christian,
Weiss Günther,
Koza Astrid,
Reibnegger Gilbert,
Daxenbichler Günter,
Zeimet Alain G.,
Fuchs Dietmar,
Wachter Helmut,
Dapunt Otto
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910580105
Subject(s) - neopterin , immune system , cancer , medicine , immunology , oncology , cancer research
Granulocyte colony‐stimulating factor (G‐CSF) and granulo‐cyte‐macrophage colony‐stimulating factor (GM‐CSF) have recently been introduced in the treatment of chemotherapy‐induced neutropenia. Effects of these CSFs on the cellular immune system were evaluated in 38 neutropenic gynecological cancer patients during chemotherapy. In addition to restoring the leukocyte count, GM‐CSF‐to a greater extent than G‐CSF—also induced neopterin, a sensitive marker of macro‐phages activated by interferons. This effect was confirmed in vitro by investigating the effects of these CSFs on interferon‐γ‐mediated pathways in THP‐1 human myelomonocytic cells. The results suggest activation of immune effector cells by GM‐CSF. © 1994 Wiley‐Liss, Inc.