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Reactivity of lung tumors with lung‐derived and non‐lung‐derived monoclonal antibodies
Author(s) -
Ioachim H. L.,
Pambuccian S.,
Giancotti F.,
Dorsett B.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910570729
Subject(s) - monoclonal antibody , pathology , immunohistochemistry , lung , antigen , enolase , small cell lung carcinoma , antibody , large cell , carcinoma , biology , medicine , immunology , small cell carcinoma , adenocarcinoma , cancer
The reactivity of 74 lung‐derived monoclonal antibodies (MAbs) provided by the Third International Workshop on Lung Tumor Antigens and of 41 non‐lung‐derived commercially available MAbs against sections of 15 lung tumors of various histologic types was investigated by immunohistochemistry. Three MAbs with specificity for human neural‐cell adhesion molecule (H‐NCAM) and 3 MAbs with specificity for small‐cell lung carcinoma (SCLC) were able to distinguish between neuroendocrine (NE) and non‐NE tumors. Fifteen MAbs stained non‐small‐cell carcinomas (NSCLC) but not SCLC. Neuron‐specific enolase (NSE) stained all NE tumors but also some of the non‐NE tumors. Two MAbs showed specificity for mesotheliomas. Carcino‐embryonic MAb strongly stained all SCLC and NSCLC. Among MAbs with lymphoid‐cell specificities, Leu 7 (CD57) stained SCLC, but not NSCLC. LN2 (CD45R), LN3 (HLA‐DR), Leu 22 (CD43) and BLA 36 reacted with NSCLC and were non‐reactive with SCLC. Some of the lung‐derived MAbs showed immune staining of lymphoma and melanoma.