Premium
Prognostic factors in renal‐cell carcinoma: Immunohistochemical detection of p53 protein versus clinico‐pathological parameters
Author(s) -
But Fredrik J.,
Godschalk Josian C. J.,
Krishnadath Kausilia K.,
Van Kwast Theo H. M. Der,
Bosman Fred T.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910570504
Subject(s) - immunohistochemistry , pathological , renal cell carcinoma , stage (stratigraphy) , pathology , carcinoma , p53 protein , medicine , clear cell , oncology , biology , paleontology
Immunoreactivity forp53 protein was assessed in 100 cases of primary renal‐cell carcinoma (RCC). The results were correlated with clinical survival data (follow‐up 24 to 84 months: mean: 39 months) and with clinico‐pathological parameters, including nuclear grade, tumour stage, cell type, tumour architecture and tumour diameter. In all, 32% of the tumours were p53‐positive; there was no difference in survival between p53‐positive and ‐negative cases. Similarly, p53 expression did not correlate with any of the clinico‐pathological parameters mentioned. Nuclear grade (grade 1 + 2 vs. grade 3 + 4) had a striking impact on prognosis and so, to a lesser extent, did tumour stage and the occurrence of a spindle‐cell component. The immunohistochemical detection of p53 in RCC is not of prognostic value. The estimation of nuclear grade, however is a major predictor of prognosis.