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Inhibition of tumour promotion by various palm‐oil tocotrienols
Author(s) -
Goh S. H.,
Hew N. F.,
Norhanom A. W.,
Yadav M.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910570415
Subject(s) - tocotrienol , raji cell , palm oil , tumor promotion , in vitro , epstein–barr virus , vitamin e , lymphoblast , virus , chemistry , biochemistry , biology , cell culture , cancer research , tocopherol , immunology , gene , antioxidant , carcinogenesis , food science , genetics
Inhibition of tumour promotion by various vitamin E compounds (tocopherols and tocotrienols) and some of their dimers was examined by an in vitro assay utilizing the activation of Epstein‐Barr virus (EBV) early antigen (EA) expression in EBV‐genome‐carrying human lymphoblastoid cells. The results reveal that γ‐ and δ‐tocotrienols derived from palm oil exhibit a strong activity against tumour promotion by inhibiting EBV EA expression in Raji cells induced by 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). However, α‐ and γ‐tocopherols and dimers of γ‐tocotrienol or γ‐tocopherol lack this activity. © 1994 Wiley‐Liss, Inc.