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The genotypes and prognostic significance of human papillomaviruses in cervical cancer
Author(s) -
Chen TzerMing,
Chen ChiAn,
Wu ChihCheng,
Huang SuCheng,
Chang ChinFeng,
Hsieh ChangYao
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910570209
Subject(s) - adenosquamous carcinoma , adenocarcinoma , cervical cancer , medicine , incidence (geometry) , stage (stratigraphy) , metastasis , clinical significance , genotype , oncology , hpv infection , cancer , carcinoma , pathology , biology , gene , biochemistry , physics , optics , paleontology
An integrated study on the role of human papillomaviruses (HPV) in cervical cancer has been conducted. Out of a total of 433 cases of cervical cancer, HPV‐DNA was detected in 342 (79%) using the polymerase chain reaction (PCR). The incidence of HPV infection was not significantly related to histological types, although a lower incidence was noted in adenocarcinonu cases. The incidence of lymph node (LN) metastasis in adenosquamous carcinoma (55.6%) was significantly higher than in squamous cell carcinoma (SCC) and adenocarcinoma. HPV 16 was detected significantly more often in SCC than in adenocarcinoma. In contrast, HPV 18 was detected more often in adenocarcinoma than in SCC. As a whole, pelvic LN metastases were found in 24.3% of HPV + cases, significantly higher than 11% of HPV − cases. However, the significant association of HPV‐DNA with LN metastasis was only noted in stage I but not stage II. As far as histological types were concerned, the incidence of positive LN was; HPV + SCC >HPV‐ SCC ( p < 0.01), whereas HPV − adenocarcinoma > HPV + adenocarcinoma ( p = 0.12). Genotypes of HPV did not have any effect on nodal status. The presence and types of HPV were not associated with tumor size and distribution of clinical stage. Our results suggest that the prognostic significance of HPV‐DNA on nodal status is dependent on histological types while the genotypes of HPV cannot account for prognostic significance in cervical cancer. © 1994 Wiley‐Liss, Inc.