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Molecular analysis of chromosomh 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors
Author(s) -
Bello M. Josefa,
Vaquero Jesus,
De Campos Jose M.,
Kusak M. Elena,
Sarasa Jose L.,
SaezCastresana Javier,
Pestana Angel,
Rey Juan A.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910570207
Subject(s) - oligodendroglial tumor , oligodendroglioma , glioma , biology , pathology , anaplastic astrocytoma , glioblastoma , cancer research , idh1 , loss of heterozygosity , brain tumor , chromosome , glial tumor , astrocytoma , gene , allele , medicine , mutation , genetics
Alterations of the short arm of chromosome I are recurrently found in cytogenetic analysis of malignant gliomas, and deletions of Ip36‐p32 region characterize at least the higher‐grade tumors, glioblsstoma multiforme. Molecular analysis of tumor‐derived and normal genomic DNA from 57 cases of gliomas, using a panel of chromosome I‐specific DNA probes showed LOH in 16 tumors. Allelic losses on I p were primarily restricted to glioblastoma multiforme (2/II) and to tumors with a major oligodendroglial component: grade II oligodendrogliomas (6/6), grade III anaplastic oligodendrogliomas (5/6) and grade II‐III mixed oligo‐astrocytomas (2/3). Losses for Iq markers were detected in only I tumor (glioblastoma multiforme). Our data suggest that anomalies of Ip primarily characterize oligodendrogliomas, whereas they are rare events in astrocytic tumors and indicate that a tumor‐suppressor gene on I p36‐p32 is involved in the development of brain tumors with oligodendroglial differentiation. © 1994 Wiley‐Liss, Inc.