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Increased mutagen sensitivity in head‐and‐neck squamous‐cell carcinoma patients, particularly those with multiple primary tumors
Author(s) -
Cloos Jacqueline,
Braakhuis Boudewijn J. M.,
Steen Ivar,
Copper Marcel P.,
De Vries Nico,
Nauta Jos J. P.,
Snow Gordon B.
Publication year - 1994
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910560610
Subject(s) - mutagen , bleomycin , head and neck cancer , head and neck squamous cell carcinoma , oncology , medicine , risk factor , carcinoma , cancer research , cancer , pathology , carcinogen , biology , genetics , chemotherapy
Mutagen sensitivity is a constitutional factor which may be used to identify head‐and‐neck squamous‐cell carcinoma (HNSCC) patients at high risk for the development of multiple primary tumors (MPT). In this retrospective study, mutagen sensitivity was measured in HNSCC patients with a single primary tumor (SPT), HNSCC patients who have already developed MPT and control subjects with no tumor history. In vitro , lymphocytes were challenged with bleomycin and chromosomal damage was quantified by scoring chromatid breaks of 100 cells. A significant difference in the mean number of breaks per cell (b/c) was found between SPT patients and controls. Patients with MPT showed a significantly higher mean b/c value than SPT patients. This increase in mutagen sensitivity in HNSCC patients was not related to well‐known cancer risk factors such as age, or life‐style factors such as smoking and alcohol drinking habits. In addition, tumor site but not tumor stage was found to be related to mutagen sensitivity. On the basis of our findings, we propose that mutagen sensitivity is not an independent risk factor but a constitutional factor which reflects the way in which genotoxic compounds are dealt with and is thereby directly related to cancer risk.