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Enhanced expression of LFA‐3 on human T‐cell lines and leukemic cells carrying human T‐cell‐leukemia virus type 1
Author(s) -
Imai Toshio,
Tanaka Yoshikazu,
Fukudome Kenji,
Takagi Shin,
Araki Koichi,
Yoshie Osamu
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910550520
Subject(s) - cell culture , biology , cell adhesion molecule , immunoglobulin superfamily , leukemia , lymphocyte function associated antigen 1 , homing (biology) , integrin , microbiology and biotechnology , cell adhesion , cell , t cell leukemia , receptor , jurkat cells , virology , human t lymphotropic virus 1 , t cell , intercellular adhesion molecule 1 , immunology , immune system , genetics , ecology
Previously, we studied the surface expression of LFA‐1 (CD 11 a/CD 18) and ICAM‐1 (CD54) in a panel of 16 human T‐cell lines and found that those carrying HTLV‐1 pro‐viruses expressed high levels of ICAM‐1. Enhanced expression of ICAM‐1 was also seen in fresh leukemic cells from ATL patients. In the present study, we systematically examined the surface expression of 19 different cell‐adhesion molecules (CAMs) (the immunoglobulin superfamily, the homing receptors, the integrins, etc.) in a panel of 20 human T‐cell lines (6 HTLV‐1‐negative lines and 14 HTLV‐1‐positive lines). The surface expression of LFA‐3 (CD58) was constantly enhanced in HTLV‐1‐positive T‐cell lines except for MT‐1, an ATL‐derived cell line, which was devoid of a number of CAMs including ICAM‐1. LFA‐3 proteins and mRNA were found at strongly increased levels in HTLV‐1 ‐positive T‐cell lines.