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Epstein‐barr virus subtype distribution in angioimmunoblastic lymphadenopathy
Author(s) -
Borisch Bettina,
Caioni Massimo,
Hurwitz Nina,
DommannScherrer Corina,
Odermatt B.,
Waelti Ernst,
Hubert R. Hubert,
Kraft Rainer,
Laissue Jean
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910550509
Subject(s) - virus , virology , epstein–barr virus , medicine , distribution (mathematics) , pathology , mathematical analysis , mathematics
The tissues of 16 patients bearing a T‐cell lymphoma of angioimmunoblastic lymphadenopathy type (AILD‐TCL) were investigated for the distribution of Epstein‐Barr virus (EBV) subtypes 1and 2. EBV‐association had been proven in these cases by polymerase chain reaction (PCR) for EBV‐DNA, in situ hybridization (ISH) for EBV‐encoded small nuclear RNAs (EBER) and immunohistology for EBV‐encoded latent membrane protein (LMP). PCR and EBER‐ISH produced mostly identical results, but some cases were positive with only one of the 2 methods employed. LMP was detected in a few large cells of 8/13 cases. Twelve cases were investigated for the distribution of EBV subtypes. One case contained EBV genome of subtype 2, 3 cases contained subtype 1 and 4 cases contained both subtypes. Four cases could not be typed. These finclings suggest that in AILD, as in AIDS‐associated lymphomas and lymphomas of the lethal midline granuloma type, subtype 2 of EBV may occur, perhaps in relation to an immunodysfunction developing progressively in these patients.