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Inhibitory effects of 3′‐methyl‐3‐hydroxy‐chalcone on proliferation of human malignant tumor cells and on skin carcinogenesis
Author(s) -
Satomi Yoshiko
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910550330
Subject(s) - chalcone , carcinogenesis , hela , cancer research , cell growth , chemistry , flow cytometry , cell culture , cancer , microbiology and biotechnology , biology , cell , medicine , biochemistry , stereochemistry , genetics
3′‐methyl‐3‐hydroxy‐chalcone (3Me‐3‐C), a derivative of chalcone, inhibited the proliferation of various kinds of human malignant tumor cells, such as HGC‐27 (gastric cancer), HeLa (cervical carcinoma), PANC‐1 (pancreatic cancer) and GOTO (neuroblastoma). Flow‐cytometric analysis of HGC‐27 cells revealed that 3′Me‐3‐C perturbed the cell cycle, i.e., it delayed passage through the S phase, and/or caused arrest in the G 0 /G 1 phase. 3′Me‐3‐C inhibited the binding of [6,7‐ 3 H]estradiol to type‐II estrogen‐binding sites dose‐dependently, and altered the pattern of protein synthesis and phosphorylation, which may explain 3Me‐3‐C‐induced inhibition of cell proliferation. In addition, 3Me‐3‐C also suppressed the promoting activity of 12‐0‐tetradecanoylphorbol‐13‐acetate on skin carcinogenesis in 7,12‐dimethylbenz[a]anthracene‐initiated mice.