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Expression of the c‐erbB‐3 gene product in gastric cancer
Author(s) -
Sanidas E. E.,
Filipe M. I.,
Linehan J.,
Lemoine N. R.,
Gullick W. J.,
Rajkumar T.,
Levison D. A.
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910540612
Subject(s) - intestinal metaplasia , immunohistochemistry , dysplasia , gene product , pathology , carcinogenesis , cytoplasm , positive staining , cancer , biology , gene expression , gastric mucosa , staining , gene , cancer research , medicine , stomach , genetics , biochemistry
The pattern of c‐erbB‐3 gene product was studied in 91 advanced gastric carcinomas, adjacent hyperplastic mucosa, intestinal metaplasia and dysplasia and in normal controls, using immunohistochemistry in archival material. All tumours showed positive c‐erbB‐3 staining in both cytoplasm and membrane. No significant differences of expression were observed between intestinal and diffuse‐type carcinomas or any other clinical parameters. Of interest is the expression in the adjacent mucosa, which is extensive, cytoplasmic, and of lower intensity than in the tumours. Further studies are currently being carried out to clarify the role of this protein in tumour behaviour and gastric carcinogenesis.