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Loss of heterozygosity on chromosome 13 and its association with delayed growth of retinoblastoma
Author(s) -
Kato Mitsuo V.,
Ishizaki Kanji,
Ejima Yosuke,
Kaneko Akihiro,
Tanooka Hiroshi,
Sasaki Masao S.
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910540609
Subject(s) - loss of heterozygosity , retinoblastoma , chromosome , family history , medicine , somatic cell , pathology , biology , genetics , allele , gene
Loss of heterozygosity (LOH) on chromosome 13 and the age of patients at operation were studied in 46 cases of retinoblas‐toma (RB) tumors, of which 25 were hereditary and 21 were non‐hereditary. The frequency of LOH was 70% for all informative tumors, but significantly higher in non‐hereditary tumors (90%) than in hereditary ones (52%). Our results suggest that LOH might be involved in the initial somatic events in non‐hereditary tumors. Age at operation of patients with hereditary tumors was significantly lower than that of patients with non‐hereditary tumors. Even when tumors associated with a family history were omitted from among the hereditary cases, the difference was still significant. In the case of hereditary tumors, age at operation of LOH‐negative patients was significantly lower than that of LOH‐positive patients. When tumors associated with a family history were omitted, the difference was still significant. The delay in development of LOH‐positive tumors suggests that LOH for one chromosome 13 may be disadvantageous with respect to growth of RB tumors.