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Subtypes of epstein‐barr virus in HIV‐1‐associated and HIV‐1‐unrelated hodgkin's disease cases
Author(s) -
De Re Valli,
Boiocchi Mauro,
De Vita Salvatore,
Dolcetti Riccardo,
Gloghini Annunziata,
Uccini Stefania,
Baroni Carlo,
Scarpa Aldo,
Cattoretti Giorgio,
Carbone Antonino
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910540603
Subject(s) - virology , disease , human immunodeficiency virus (hiv) , virus , epstein–barr virus , viral disease , gammaherpesvirinae , medicine , immunology , biology , herpesviridae , pathology
Epstein‐Barr virus (EBV) type 2 is considered to be a much less potent transformer of lymphocytes than type‐1. However, type‐2 EBV may be involved in the pathogenesis of non‐Hodgkin's lymphomas (NHLs) arising in immunocompromised patients, i.e., subjects with malaria or HIV‐1 infection. To determine whether type‐2 EBV may also play a role in Hodgkin's disease (HD) developing in immunocompromised patients, we characterized EBV subtypes in EBV‐positive HD samples from 10 HIV‐1‐positive patients as well as from a control population of 24 HIV‐1 ‐negative patients. Type‐2 EBV was detected in 5/10 HD samples from the HIV‐1‐positive group (I case showed concomitant type‐1 EBV positivity), but only in 1/20 HD samples from the HIV‐1 ‐negative group, indicating that, during HIV‐1 ‐induced immunodepression, type‐2 EBV may be pathoge‐netically involved also in HD, as previously reported for HIV‐associated NHLs.