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Allelic loss in ovarian cancer
Author(s) -
YangFeng Teresa L.,
Han Hong,
Chen KuangChao,
Li ShiBo,
Claus Elizabeth B.,
Carcangiu Maria L.,
Chambers Setsuko K.,
Chambers Joseph T.,
Schwartz Peter E.
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910540405
Subject(s) - loss of heterozygosity , biology , ovarian cancer , gene duplication , locus (genetics) , allele , genetics , monosomy , chromosome 17 (human) , breast cancer , chromosome , cancer research , chromosome 13 , karyotype , cancer , gene
Loss of heterozygosity (LOH) was examined at 86 loci distributed on every chromosomal arm in 50 human ovarian tumors. Frequent allele losses were observed on chromosomes 13q (42%), 17p (42%), 17q (45%), and Xp (41%). Deletion mapping on chromosome 17 revealed a candidate gene on the long arm distal to D17S41/S74 for ovarian cancer which is distant from the locus for early onset breast cancer. LOH on chromosome 17q was found to be concordant with LOH on chromosomes 3p, 13q, 17p and Xp suggesting that it may be an early event in neoplastic development. These findings indicate that multiple tumor‐suppressor genes for ovarian cancer possibly exist on chromosomes 13q, 17, and/or Xp and provide the basis for the identification of candidate gene(s) associated with ovarian cancer. The chromosomal mechanisms resulting in allele losses in ovarian cancer include deletion, deletion/duplication, mitotic recombination and monosomy, in concordance with the developed genetic model.