Premium
Amplification of fgfr 4 gene in human breast and gynecological cancers
Author(s) -
Jaakkola Susanna,
Salmikangas Paula,
Nylund Stella,
Lehtovirta Pentti,
Nevanlinna Heli,
Partanen Juha,
Armstrong Elina,
Pyrhönen Seppo
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910540305
Subject(s) - gene duplication , medicine , breast cancer , ovarian cancer , cancer research , metastasis , amplicon , pathology , carcinogenesis , endometrial cancer , cancer , oncology , biology , gene , polymerase chain reaction , biochemistry
Abstract We have investigated gene amplification of fibroblast growth factor receptor‐4 (FGFR4) gene in 30 primary breast tumor samples and 15 gynecological tumor samples. Ten percent of the breast tumors showed 2‐ to 4‐fold amplification. Amplification was found more frequently in estrogen‐ and progesterone‐receptor‐positive tumors and in tumors with high lymph‐node involvement. Breast tumor samples were also analyzed for the amplification of fgfr 3 and erbB2 genes and the chromosome I Iq 13 located genes hst I Iint 2 lbci 1 /sea . erbB2 gene was amplified 2‐ to 13‐fold in 13% of the cases, but no amplification of int2/hst I/be/1/sea amplicon was found. Gynecological tumors were also analyzed for the amplification of fgfr 4 and fgfr 3 genes and for int2 and hst I oncogenes. Eleven of the 15 gynecological tumors were ovarian neoplasms including 2 benign tumors; the remainder comprised I ovarian metastasis of breast cancer; I endometrial cancer; I uterine leiomyosarcoma and I carcinosarcoma of the fallopian tube. In gynecological tumors, fgfr 4 gene was found to be amplified in 2 ovarian tumors. Amplification of hst I was found in I benign ovarian tumor. Thus, the fgfr 4 gene may be involved in breast and ovarian tumorigenesis.