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Expression of the MuLV‐tumor‐associated antigen is restricted to MuLV‐transformed cells
Author(s) -
Flyer David C.,
Sucheski Brian
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910540227
Subject(s) - ctl* , murine leukemia virus , antigen , virology , population , biology , spleen , virus , leukemia , immunology , microbiology and biotechnology , medicine , cd8 , environmental health
Immunization of mice with Moloney murine leukemia virus (MoMuLV) induces the generation of a population of CTL which recognizes a non‐viral, tumor‐associated antigen (TAA) expressed on MuLV‐induced tumors. To determine whether this TAA could be used as a pre‐leukemic or leukemic cell marker, CTL clones directed against Moloney viral and TAA antigen were used to analyze viral and TAA antigen expression on chronically infected and leukemic lymphoid cells obtained from mice inoculated neonatally with MoMuLV. Although both sets of cells could be recognized and lysed by viral antigen specific CTL, they are not recognized by TAA‐specific CTL. Only after transformed cell lines were established from leukemic spleen cells could susceptibility to TAA‐specific CTL be observed. Thus, the appearance of the MoMuLV‐TAA was restricted to MoMuLV‐transformed cells.