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TGF‐β induces an inhibitory effect of normal cells directed against transformed cells
Author(s) -
Höfler P.,
Wehrle I.,
Bauer G.
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910540120
Subject(s) - transforming growth factor , inhibitory postsynaptic potential , microbiology and biotechnology , biology , transforming growth factor beta , carcinogenesis , chemistry , endocrinology , biochemistry , gene
Co‐cultivation of normal and transformed fibroblasts in the presence of exogenously added transforming growth factor type beta 1 (TGF‐β1) leads to a drastic reduction of colony‐forming transformed cells. This inhibitory effect is dependent both on the dose of TGF‐β applied and the density of normal cells. It does not reflect a direct action of TGF‐β on transformed cells, but is rather induced by TGF‐β in normal cells. In the absence of exogenously added TGF‐β, normal cells exhibit a basal inhibitory activity, which can be abrogated by anti‐TGF‐β. TGF‐β‐mediated inhibition of transformed cells by normal cells may be considered as a novel potent controlling step in carcinogenesis.