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Allelic loss on chromosome 17 in human ovarian cancer
Author(s) -
Phillips Nancy,
Ziegler Michelle,
Saha Bratin,
Xynos Francisco
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910540115
Subject(s) - loss of heterozygosity , locus (genetics) , biology , ovarian cancer , tumor suppressor gene , cancer research , allele , ovarian carcinoma , chromosome 17 (human) , deletion mapping , metastasis , chromosome , gene , carcinogenesis , cancer , genetics
In order to identify a common region of deletion on chromosome 17 potentially containing a tumor‐suppressor gene, 27 ovarian carcinomas and 3 ovarian tumors of low malignant potential (LMP) were examined for loss of heterozygosity (LOH) at 6 p arm and 10 q arm loci. Ninety percent of all tumors had deletions at one or more loci. On the p arm, there was a single near‐common region of deletion on 17p 13.3 (D/7S30/ pYNZ22.1; 86% LOH), an intervening locus with a low LOH rate, and a more proximal locus on 17p11.2 (D/7S58/pEW301; 82% LOH) with a high LOH rate. In less aggressive tumors, LOH at Df 7S30 was not accompanied by LOH at p53 . The q arm had a common region of deletion for high‐stage carcinoma at D/7S579 (Mfd 188; 74% LOH) on q21, a locus tightly linked to the familial breast‐ovarian‐cancer syndrome (BRCAI) locus. D/7S579 was lost in all informative high‐stage carcinomas and retained in all low‐stage carcinomas and tumors of LMP. There may be at least 2 tumor‐suppressor genes, an early‐acting gene on the p arm and a gene on the q arm involved in tumor progression and metastasis.