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Correlation between the lung distribution patterns of Lu‐Ecam‐1 and melanoma experimental metastases
Author(s) -
And Duzhang Zhu,
Pauli Bendicht U.
Publication year - 1993
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910530417
Subject(s) - melanoma , pathology , staining , biology , lung , immunohistochemistry , blood vessel , cancer research , medicine , endocrinology
Lu‐ECAM‐1 is a 90‐kDa lectin‐like, melanoma‐cell‐binding endothelial‐cell adhesion molecule that mediates colonization of the lungs by B16‐FIO melanoma cells. The well‐known formation of pleural and sub‐pleural B 16‐F10 melanoma colonies is correlated quantitatively with prominent histochemical staining of endothelia of pleural capillaries and sub‐pleural venules with anti‐Lu‐ECAM‐I MAb 6D3. The less frequent endothelial staining of perivenous and peribronchial venules is associated with fewer B16‐F10 colonies in these locations, and the occasional segmental staining of pulmonary veins coincides with rare tumor nodules which usually expand in an asymmetric fashion around these veins. Lu‐ECAM‐I is also expressed on endothelia of some tumor vessels, indicating that these vessels are recruited from the same host blood vessels that originally caused the arrest of blood‐borne B16‐F10 melanoma cells. The close association between the lung distribution patterns of Lu‐ECAM‐I‐positive blood vessels and experimental melanoma metastases is further evidence of the importance of endothelial‐ cell adhesion molecules in the formation of metastases.