Smoking‐related dna adducts in human gastric cancers | Zendy

Dyke G. W. | Zendy; Craven J. L. | Zendy; Hall R. | Zendy; Garner R. C. | Zendy

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Smoking‐related dna adducts in human gastric cancers

Author(s) -

Dyke G. W.,

Craven J. L.,

Hall R.,

Garner R. C.

Publication year - 1992

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910520602

Subject(s) - adduct , nucleotide , dna , cancer , dna adduct , epidemiology , medicine , biology , microbiology and biotechnology , chemistry , genetics , gene , organic chemistry

DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non‐smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the 32 P‐post‐labelling method. Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/10 8 nucleotides to 60 adducts/10 8 nucleotides. In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non‐smokers. These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer. © 1992 Wiley‐Liss, Inc.

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