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A population‐based case‐control study of cancers of the nasal cavity and paranasal sinuses in Shanghai
Author(s) -
Zheng Wei,
Blot William J.,
Shu XiaoOu,
Diamond Earl L.,
Gao YuTang,
Ji BuTian,
Fraumeni Joseph F.
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910520410
Subject(s) - medicine , paranasal sinuses , nasal cavity , population , cancer , case control study , physiology , risk factor , surgery , environmental health
A population‐based case‐control study of cancer of the nasal cavity and sinuses, involving interviews of 60 incident cases and 414 controls, was conducted in Shanghai. Cigarette smoking was associated with a mild elevation in risk of squamous‐cell carcinoma but not cancers of other cell types. Occupational exposures to wood and silica dusts and to petroleum products, and the use of wood and straw as cooking fuel, were linked to moderate increases in risk, while 4‐fold or greater increases were associated with a history of chronic nasal diseases, including those occurring 10 or more years prior to cancer diagnosis. Dietary analyses revealed a significant protective effect of consumption of allium vegetables, oranges and tangerines, with a 50% reduced risk of nasal cancer among individuals in the highest intake group of these foods. Consumption of salt‐preserved vegetables, meat and fish was associated with a significantly increased risk of nasal cancer in a dose‐response fashion, with a 5‐fold excess observed for the heaviest intake of these salted foods. These findings suggest that dietary factors may contribute to the development of nasal cancer. © 1992 Wiley‐Liss, Inc.