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The human squamous cervical carcinoma cell line, HOG‐1, is responsive to steroid hormones
Author(s) -
White J. O.,
Jones R. N.,
Croxtall J. D.,
Gleeson R. P.,
Krausz T.,
Pervez S.,
Jamil A.,
Guida L.,
Beesley J. E.,
Soutter W. P.
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910520216
Subject(s) - medroxyprogesterone acetate , steroid , hormone , endocrine system , cervical carcinoma , medicine , endocrinology , steroid hormone , cell culture , basal (medicine) , basal cell , medroxyprogesterone , human breast , estrogen , cervical cancer , cancer , biology , breast cancer , genetics , insulin
Growth of the human squamous cervical carcinoma cell line, HOG‐1, was stimulated in response to oestradiol in serum‐containing and chemically defined medium. The oestradiol‐stimulated growth could be inhibited by 4‐OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also inhibited basal cell growth in serum‐containing and chemically defined media. The data are consistent with the sensitivity of human squamous cervical cancer to sex‐steroid hormones and suggest that endocrine therapies may be of benefit in this disease. © 1992 Wiley‐Liss, Inc.