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Protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine‐induced hamster oral carcinogenesis
Author(s) -
Azuine Magnus A.,
Bhide Sumati V.
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910510313
Subject(s) - nitrosamine , hamster , carcinogenesis , betel , medicine , carcinogen , traditional medicine , biology , cancer , genetics , structural engineering , nut , engineering
The inhibitory effect of oral administration of betel‐leaf extract (BLE) and 2 of its constituents, β‐carotene and α‐tocopherol, as single agents or in combination with dietary turmeric on methyl(acetoxymethyl)nitrosamine (DMN‐OAC)‐induced oral carcinogenesis in Syrian hamsters was studied. DMN‐OAC was administered twice monthly for 6 months. The chemopreventive effect of BLE or its constituents with turmeric was determined by comparing tumor incidence observed in treated groups with that seen in control animals. The apparent sitespecific chemopreventive effect of BLE or its constituents was demonstrated by inhibition of tumor incidence, reduction of tumor burden, extension of the tumor latency period and regression of established, frank tumors. The inhibitory effect of BLE or its constituents combined with turmeric was higher than that of the individual constituents. The study suggests that BLE could be developed as a potential chemopreventive agent for human oral cancer.