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The content of urokinase‐type plasminogen activator antigen as a prognostic factor in urinary bladder cancer
Author(s) -
Hasui Yoshihiro,
Marutsuka Kousuke,
Suzumiya Junji,
Kitada Shinichiro,
Osada Yukio,
Sumiyoshi Akinobu
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500607
Subject(s) - bladder cancer , plasminogen activator , urokinase , cancer , medicine , antigen , urinary bladder , metastasis , urinary system , immunoassay , pathology , gastroenterology , urology , oncology , immunology , antibody
Urokinase‐type plasminogen activator (u‐PA) is thought to be implicated in cancer invasion and metastasis. The aim of this study was to determine whether the u‐PA content of cancer tissue is a prognostic factor in bladder cancer. Tissue samples from 46 patients with bladder cancer were assessed for u‐PA antigen by a highly sensitive enzyme immunoassay. The relationships between the u‐PA level in extracts of bladder cancer and the survival rates of the bladder‐cancer patients were examined. Patients with a high u‐PA level (8 ng/mg of protein and more) showed a statistically significantly higher rate of survival than those with a low u‐PA level ( p < 0.005). The u‐PA antigen level in cancer tissue was significantly lower in low‐graded and non‐invasive cancers than in others ( p < 0.01).