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Enhancement by bombesin of colon carcinogenesis and metastasis induced by azoxymethane in wistar rats
Author(s) -
Iishi Hiroyasu,
Tatsuta Masaharu,
Baba Miyako,
Yamamoto Reiko,
Taniguchi Haruo
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500529
Subject(s) - azoxymethane , bombesin , medicine , peritoneum , metastasis , colorectal cancer , lymph , adenocarcinoma , pathology , gastroenterology , cancer , endocrinology , receptor , neuropeptide
The effects of bombesin on the incidence, number and histology of colon tumors induced by azoxymethane (AOM), and on their metastases to the peritoneum and/or lymph nodes, were investigated in Wistar rats. Rats received weekly s.c. injections of AOM for 10 weeks, and s.c. injections of bombesin in depot form every other day until the end of the experiment in week 30. Administration of bombesin significantly increased the incidence of colon tumors in week 30. It had no influence on the histological features or depths of involvement of colon adenocarcinomas, but significantly increased the incidence of cancer metastasis to the peritoneum and/or lymph nodes. It also caused a significant increase in the labeling index of the colon epithelial cells. Our findings indicate that bombesin enhances the development and metastasis of colon tumors, and that this effect may be related to its effect in increasing proliferation of epithelial cells of the colon.