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Reconstituted basement membrane (matrigel) promotes the survival and influences the growth of murine tumors
Author(s) -
Vukičević Slobodan,
Somogyi Lehel,
Martinović Igor,
Žic Rado,
Kleinman Hynda K.,
Marušić Matko
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500521
Subject(s) - basement membrane , matrigel , in vivo , biology , pathology , malignancy , cancer research , medicine , microbiology and biotechnology
The effects of reconstituted basement membrane (Matrigel) on in vivo survival and growth of several murine tumors were studied. Survival of tumor cells was enhanced in all experiments which resulted in increased incidence and/or in increased tumor mass. While basement membrane enhanced the in vivo growth of B16F6 melanoma cells, survival of these mice was prolonged. Basement membrane increased the incidence but reduced the growth of Ehrlich ascites tumor. Walker‐256 hypercalcemic breast carcinosarcoma growth was enhanced and glandular‐like structures were observed when grown on Matrigel. The results indicate that the enhanced survival of tumor cells in the presence of basement membrane is not unequivocally linked with increased malignancy.