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Micronucleus formation in peripheral‐blood lymphocytes from smokers and the influence of alcohol‐ and tea‐drinking habits
Author(s) -
Xue KaiXian,
Wang Su,
Ma GuoJian,
Zhou Ping,
Wu PanQuan,
Zhang RuiFeng,
Xu Zhen,
Chen WenSheng,
Wang YouQin
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500506
Subject(s) - micronucleus test , peripheral blood , alcohol , micronucleus , medicine , physiology , peripheral , alcohol intake , carcinogen , immunology , toxicology , toxicity , biology , genetics , biochemistry
Abstract In recent years, studies on the genotoxic effects of smoking and its modifying factors have been widely followed with interest. In this report, frequencies of micronuclei (MNF) in peripheral‐blood lymphocytes in 220 healthy smokers have been detected by the micronucleus test by finger‐skin puncture, which needs only 1 to 2 drops of peripheral blood. On the basis of analysis of matched‐pair data, the modifying effects of alcohol and tea are discussed. Our results show that (1) smoking significantly increases MNF in lymphocytes as compared with healthy non‐smokers ( p < 0.01); (2) alcohol significantly increases MNF in smokers ( p < 0.01); (3) tea decreases MNF induced by smoking ( p < 0.01). Therefore, the anti‐carcinogenic role of tea merits further study.