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Potent anti‐tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (maxim) franquet
Author(s) -
Yu Lijian,
Ma Rundi,
Wang Yongqing,
Nishino Hoyoku,
Takayasu Junko,
He Weizhen,
Chang Mei,
Zhen Jie,
Liu Wensheng,
Fan Suxian
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500425
Subject(s) - arachidonic acid , bulb , maxim , carcinogenesis , traditional medicine , phytotherapy , medicine , edema , pharmacology , cancer , biology , biochemistry , pathology , botany , alternative medicine , political science , law , enzyme
Tubeimoside 1, one of the new triterpenoid saponins from the bulb of Bolbostemma paniculatum (Maxim) Franquet, had an anti‐inflammatory effect on mouse ear edema induced by arachidonic acid and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA). Furthermore, a potent anti‐tumorigenic effect of tubeimoside I was observed in 2‐stage carcinogenesis of mouse skin after oral administration as well as topical application. Thus, tubeimoside I appears to be a promising agent for cancer chemoprevention.