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Regulation of leukocyte binding to endothelial tissues by tumor‐derived GM‐CSF
Author(s) -
Fu YangXin,
Cai JianPing,
Chin YeeHon,
Watson Gordon A.,
Lopez Diana M.
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500416
Subject(s) - infiltration (hvac) , endothelium , cell adhesion molecule , biology , cytokine , granulocyte macrophage colony stimulating factor , granulocyte , immunology , leukocyte trafficking , endothelial stem cell , pathology , cancer research , microbiology and biotechnology , inflammation , medicine , in vitro , chemokine , endocrinology , biochemistry , physics , thermodynamics
The adherence of leukocytes to endothelial cells is the first step in the migration of these cells into tumor tissues. Specific binding to the endothelial cells by leukocytes is mediated by the development and maintenance of adhesion molecules on the endothelium; however, the mechanisms of leukocyte traffic into tumors and of their interactions with neoplastic tissue are not clearly understood. The infiltration of leukocytes occurs in most spontaneous and transplanted solid tumors and we have previously reported that not only are murine mammary tumors heavily infiltrated by leukocytes but tumor‐derived factors alter the development and function of leukocytes in tumor‐bearing mice. We now present evidence that a tumor‐derived cytokine, namely granulocyte‐macrophage‐colony‐stimulating factor, appears to be of importance in the regulation of leukocyte binding to endothelial cells. The data suggest that tumor‐derived factors may influence leukocyte trafficking within tumor tissue.