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Different fatty‐acid profiles in phosphoinositides from human fibroblastic meningiomas with or without chromosome 22 monosomy
Author(s) -
Bordoni Alessandra,
Hrelia Silvana,
Biagi Pier Luigi,
Berra Bruno
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500313
Subject(s) - monosomy , chromosome , biology , genetics , chromosome 7 (human) , biochemistry , gene , karyotype
Abstract The fatty‐acid composition of phosphoinositides derived from 13 human fibroblastic meningiomas, divided according to the presence or the absence of monosomy of chromosome 22, was analyzed. Phosphoinositides were separated into their 3 main components: phosphatidylinositol, phosphatidylinositol‐4‐phosphate, and phosphatidylinositol‐4,5‐bisphosphate. In all the tumors, regardless of cytogenetic differences, remarkable differences were detected, between phosphatidylinositol and phosphatidylinositol‐4‐phosphate or phosphatidylinositol‐4,5‐bisphosphate. In meningiomas with 22 monosomy, there was a significant decrease in the relative amount of arachidonate in all the phosphoinositide fractions; this situation might determine diminished down‐regulation of the corresponding diacylglycerol, derived by the phospholipase‐C‐stimulated hydrolysis of phosphoinositides, and, consequently, different protein‐kinase‐C stimulation.