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Sister chromatid exchanges and chromosome aberrations in lymphocytes of nurses handling antineoplastic drugs
Author(s) -
GoloniBertollo Eny Maria,
Tajara Eloiza Helena,
Manzato Antonio José,
VarellaGarcia Marileila
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500302
Subject(s) - sister chromatids , sister chromatid exchange , chromatid , chromosome , antineoplastic drugs , medicine , lymphocyte , genetics , nursing , biology , pharmacology , dna , gene
Chromosomal aberrations (CA) and sister‐chromatid exchanges (SCE) were investigated in peripheral lymphocytes of 15 nurses and nurse's aides handling cytostatic agents in hospital oncology units. Significantly increased frequencies were noted for both CA and SCE rates when the exposed individuals were compared with 15 nurses working in other hospital units and to a control sample matched by sex and age. This points to the need for emphasizing protective measures in the handling of anti‐neoplastic agents.