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Inhibition of azoxymethane‐induced experimental colon carcinogenesis in wistar rats by 6‐hydroxydopamine
Author(s) -
Tatsuta Masaharu,
Iishi Hiroyasu,
Baba Miyako,
Taniguchi Haruo
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500221
Subject(s) - azoxymethane , hydroxydopamine , medicine , histology , pathology , carcinogenesis , carcinogen , gastroenterology , biology , cancer , dopamine , dopaminergic , genetics
The effects of 6‐hydroxydopamine (6‐OHDA) on the incidence, number and histology of colon tumors induced by azoxymethane (AOM), and on norepinephrine (NE) concentration in the colon wall and the labelling index of the colon mucosa were investigated in Wistar rats. Rats received sub‐cutaneous (s.c.) injections of AOM once a week for 10 weeks, and throughout 35 weeks were also given intraperitoneal (i.p.) injections of 6‐OHDA. Prolonged administration of 6‐OHDA was found to cause a significant reduction in the incidence and number of colon tumors. However, it had no influence on the histological features or depths of involvement of colon tumors and/or adenocarcinomas. Its administration also caused significant decreases in the NE concentration in the colon wall and in the labelling index of the colon mucosa. Our findings indicate that 6‐OHDA has a protective effect against colon carcinogenesis, and that the activity of the sympathetic nervous system may have an important influence on colon carcinogenesis.