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Elevated p53 RNA expression correlates with incomplete osteogenic differentiation of radiation‐induced murine osteosarcomas
Author(s) -
Strauss P. Günter,
Mitreiter Karin,
Zitzelsberger Horst,
Luz Arne,
Schmidt Jörg,
Erfle Volker,
Höfler Heinz
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500215
Subject(s) - osteosarcoma , biology , gene expression , gene , cancer research , rna , osteoblast , tumor suppressor gene , sarcoma , cell culture , cellular differentiation , regulation of gene expression , microbiology and biotechnology , pathology , in vitro , genetics , carcinogenesis , medicine
An important role for the p53 gene in osteogenic sarcomas has been imputed by identification of somatically acquired gene alterations in human osteosarcomas and by the development of osteosarcomas in p53 transgenic mice. To study the involvement of p53 in radiation‐induced osteosarcomagenesis, we have investigated gene alterations and expression of p53 in radiationinduced murine osteosarcomas and tumor‐derived cell lines. Eighteen of 31 tumors and 8 of 9 cell lines showed alterations in the p53 gene region, or elevated levels of p53 RNA. Expression of the osteoblast marker gene bone gla protein was substantially reduced in tumors which simultaneously showed high steady‐state levels of p53 RNA. Our data indicate that p53, in addition to its function in regulating DNA synthesis, may be involved in the control of osteogenic differentiation in osteosarcomagenesis.