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Detection of human papillomavirus dna sequences in tongue squamous‐cell carcinoma utilizing the polymerase chain reaction method
Author(s) -
Shindoh Masanobu,
Sawada Yukiharu,
Kohgo Takao,
Amemiya Akira,
Fujinaga Kei
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500202
Subject(s) - polymerase chain reaction , human papillomavirus , dot blot , southern blot , dna , virology , microbiology and biotechnology , basal cell , nested polymerase chain reaction , biology , pathology , medicine , gene , genetics
Twenty‐four cases of tongue squamous‐cell carcinoma (SCC) were analyzed for human papillomavirus (HPV) DNAs by the polymerase chain reaction (PCR) method and the dot‐blot hybridization technique. HPV DNAs were detected in 8 cases. One specimen histopathologically diagnosed as poorly differentiated grade‐III SCC contained both HPV‐16 and HPV‐18 DNA, and 7 other cases contained HPV‐16 DNA.