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Immunologic aspects of fibrosis in mouse mammary carcinomas
Author(s) -
Vaage Jan
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500115
Subject(s) - fibrosis , immune system , mammary carcinoma , pathology , mammary tumor , ratón , cancer research , infiltration (hvac) , biology , medicine , immunology , carcinoma , cancer , breast cancer , physics , thermodynamics
The nature of the fibrosis associated with mammary carcinomas MC2 and MC3 was investigated in syngeneic C3H mice. Accelerated and enhanced peri‐tumor cellular and fibrotic responses and retarded tumor growth were observed in actively immunized and in adoptively immunized mice, and in mice treated with IL‐2. T lymphocytes and, particularly, macrophages were closely associated with collagen deposition at the tumors. The collagen deposition frequently resulted in the encapsulation and regression of the less invasive tumor MC2. A cellular fibrous response was not observed at tumors implanted into athymic C3H nu /nu mice. The results suggest that tumor fibrosis may in some circumstances be promoted by an immune response.