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Association between restriction fragment length polymorphism of the L‐ myc gene and lung metastasis in human breast cancer
Author(s) -
Champeme MarieHélène,
Bieciie Ivan,
Latil Alain,
Hacene Kamel,
Lidereau Rosette
Publication year - 1992
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910500103
Subject(s) - restriction fragment length polymorphism , lung cancer , breast cancer , metastasis , biology , cancer research , gene , cancer , genotype , medicine , oncology , genetics
EcoRI restriction fragment length polymorphism (RFLP) of the L‐ myc gene was examined in leukocyte DNAs isolated from 381 breast cancer patients. No differences in the patterns of L‐ myc RFLP were found between breast cancer patients and healthy individuals. However, among 97 patients who relapsed, a statistical correlation was found between L‐ myc RFLP and lung metastases ( p < 0.05). These results are in close agreement with previous findings in patients with cancer of the lung, bone or kidney, and suggest that L‐ myc RFLP may be a useful marker for predicting lung metastasis in some human cancers.